A previous study [49] proposed that the induction of hypoxia-inducible-factor-1-alpha (HIF-1α) gene expression program induced by 4-OI administration, which was downregulated in biopsies from COVID-19 patients along with NRF-2 signalling pathway, potentially contribute to NRF-2-mediated antiviral cytoprotective response. This evidence concerns the gene HIF1A and COVID-19.