Infection of k18-hACE2 mice with a recombinant SARS-CoV-2 virus lacking ORF6 induced a delayed weight loss recovery compared to infection with recombinant SARS-CoV-2 virions lacking other accessory proteins, suggesting that ORF6-deficiency enhances SARS-CoV-2 virulence [105]. The gene discussed is KRT18; the disease is infection.