Interestingly, co-treatment of Calu-3 cells with JQ-1 and ML385, a specific inhibitor of NRF-2 [77], prior to infection, led to a significant increase in viral RNA copies (Fig 7A) and infectious titers (Fig 7B and 7C) in the supernatant compared to JQ-1- and DMSO-co-treated cells, in the absence of detectable cell toxicity (Fig 7D). The gene discussed is NFE2L2; the disease is infection.