TARDBP and proteostasis deficiencies: The observed differences in magnitude of effects on lifespan seen above could result from (1) differential intracellular sensitivity of a given cell type to TDP-43 toxicity, (2) differences in severity of effects on brain homeostasis from loss of each glial cell type, or (3) from cell-type specificity in non-cell autonomous toxic effects from TDP-43 proteinopathy [37,42].