The mutational landscape of TFH lymphoma includes genes involved in epigenetic pathways such as TET2 (up to 90%), IDH2 (20–45%), and DNMT3A (20–30%), mutations in the small GTPase RHOA (50–70%) and mutations in the TR signaling pathway including PLCG1, CD28, FYN, and VAV1 [105]. This evidence concerns the gene IDH2 and lymphoma.