However, it is useful for discerning FL variants, including the newly described BCL2 rearrangement negative, CD23+ follicle center lymphoma [12, 67], which shows a high frequency of STAT6 mutations, cutaneous follicle center lymphoma and pediatric type FL, which shows frequent alterations of TNSFRSF14, MAP2K1, and IRF8, distinct from adult FL [92]. The gene discussed is MAP2K1; the disease is follicular lymphoma.