CD4 and nonpapillary renal cell carcinoma: In the ccRCC cohort, the proportion of naive B cells, CD8+ T cells, activated CD4+ memory T cells, Tfh cells, and macrophages M1 were higher in the high-risk group, while resting CD4+ T memory cells, resting NK cells, macrophages M2, and resting mast cells were higher in the low-risk group (Figure 4D).