In addition, correlation analysis of these tumor infiltrating immune cells and CCCP risk score revealed that the infiltration level of macrophages M1 (P<0.001), activated CD4 + memory T cells (P = 0.006), Tfh (P = 0.02), and activated NK cells (P = 0.04) were negatively correlated to the risk score, while naive CD4+ T cells (P < 0.001) and resting NK cells (P = 0.04) were positively correlated with the risk score (Supplementary Figure 5), suggesting that CCCP risk score was correlated with the immune activity in TME. The gene discussed is CD4; the disease is neoplasm.