Therefore, even though the Hap1 line represents a cancerous cell, GO term enrichment analysis by DAVID, and canonical pathway enrichment analysis by IPA showed strong concordance for DEGs to be involved in mechanisms of neuronal development, particularly axonal and synaptic processes, secondary to mutation of NHE6, a gene mutated in the intellectual disability disorder, CS. Here, SLC9A6 is linked to Cowden syndrome 1.