M6PR and Lysosomal disease: In this network, we also noted upregulation of multiple lysosome disease genes, genes for related neurologic disease and other endolysosome genes: TPP1, the causation for NCL type 2; CLN3, the causation for NCL type 3; GDAP2, associated with spinocerebellar ataxia; CD63, RAB7A, LAMP1, M6PR, or PLA2G15.