For example, it has recently been demonstrated that in human colorectal cancer (CRC), Pum1 and Pum2 are expressed at elevated levels and that the knockdown by siRNA of Pum1 and Pum2 in a mouse model of CRC inhibits tumour progression (Goldstrohm et al., 2018; Smialek et al., 2021; Gong et al., 2022). The gene discussed is PUM1; the disease is colorectal carcinoma.