According to the results for IVW (P = .1325; OR = 1.19; 95% CI, 0.94–1.50) and MWR (P = .1691; OR = 1.21; 95% CI, 0.92–1.57) method from the analysis on the first NAFLD datasets showed that CRP had not causal effect on NAFLD (Table 1). The gene discussed is CRP; the disease is metabolic dysfunction-associated steatotic liver disease.