PIK3R1 and myopia: In summary, based on the network analysis and bioinformatics analyses, this study suggested that the active constituents of DZP could act on intersectional targets: STAT3, PIK3CA, PIK3R1, MAPK1, MAPK3, and HSP90AA1, core targets of myopia: MIP and LGSN, “AGE-RAGE signaling” and “positive regulation of ATP metabolic process” pathways to treat myopia.