It is clear that in some cases, estrogen may have proinflammatory effects.[40] However, high doses of estrogen are associated with elevated levels of serum C-reactive protein, which is a marker of vascular risk.[41–43] During pregnancy, estrogen levels rise steadily and cause hypercoagulable state, which may be the reason for the increased risk of stroke in perinatal women.[44,45] More research is needed to understand the potential mechanism of estrogen fluctuations or changes and stroke in the future. The gene discussed is CRP; the disease is Stroke.