Song et al conducted a retrospective analysis of the TERT promoter mutation status of 3435 PTC patients, stratified into subgroups based on tumor size, revealing that the mutation frequency in the TERT promoter was reduced in all 3 subgroups with tumors ≤ 1 cm and increased significantly with tumor size.[42] Additional studies revealed that the TERT promoter mutation frequency was considerably lower in PTMC (0–4.7%) than in PTC.[43–45] In the present study, no TERT promoter mutations were detected. This evidence concerns the gene TERT and neoplasm.