TNF and obstructive sleep apnea syndrome: In addition to the generation of IL-12 and TNF-α, it can also downregulate the synthesis of IL-10 in C57BL/6J mice.[54] This noteworthy information indicated that the NF-κB-dependent signaling pathway plays an important role in the pathogenesis of OSA and suggests that NF-κB could be involved in the inhibition of IL-10.