FGF21 and metabolic disease: Fibroblast growth factor (FGF) 21, a special member of FGF superfamily, has been proven to have pleiotropic metabolic effects and many potential therapeutic action in various metabolic disorders.[11] Study showed that FGF21 in high glucose environment could inhibit the osteogenic differentiation of BMSCs.[12] FGF21 might be an efficient endogenous vasoprotective factor for calcification.[13]