CD8A and hepatocellular carcinoma: Neutrophils can directly kill cancer cells by secreting cytotoxic substances, such as ROS, nitric oxide, and neutrophil elastase.[60] DC-mediated cross-priming of tumor-specific CD8+ T cells plays a critical role in initiating and sustaining antitumor immunity.[61–64] Our data showed a positive correlation between SKA1 expression and the proportion of type 2 T helper cells, T follicular helper cells, and T helper cells in HCC tissues.