The association between VDR Fok I polymorphism and sepsis susceptibility were observed under the allelic contrast model (F vs f, P = .03, OR = 0.65, 95% CI = 0.44–0.95), dominant genetic model (FF vs Ff + ff, P = .02, OR = 0.53, 95% CI = 0.30–0.91), recessive genetic model (FF + Ff vs ff, P = .10, OR = 0.55, 95% CI = 0.28–1.11) codominance genetic model (FF vs ff, P = .03, OR = 0.39, 95% CI = 0.16–0.91). The gene discussed is VDR; the disease is Sepsis.