DHT upregulates inhibitory cytokines (e.g., TGF-α, EGF, IL-1α), which in turn upregulate MMP9,[21] excessive amounts of MMP9 may impede hair growth through interference with the hair cycle.[22] Several MMP9 inhibitors, such as Batimastat (BB-94), Marimastat (BB-2516), CGS-27023A (MMI-270), CGS-25966, Tanomastat (BAY12-9566) and Prinomastat (AG-3340), have been tested in clinical trials for different types of cancer.[30] Further research could validate the effectivity of MMP9 inhibitors in mouse model of AGA, and MMP9 inhibitor would provide an additional option for male AGA treatment. Here, EGF is linked to cancer.