TGFA and cancer: DHT upregulates inhibitory cytokines (e.g., TGF-α, EGF, IL-1α), which in turn upregulate MMP9,[21] excessive amounts of MMP9 may impede hair growth through interference with the hair cycle.[22] Several MMP9 inhibitors, such as Batimastat (BB-94), Marimastat (BB-2516), CGS-27023A (MMI-270), CGS-25966, Tanomastat (BAY12-9566) and Prinomastat (AG-3340), have been tested in clinical trials for different types of cancer.[30] Further research could validate the effectivity of MMP9 inhibitors in mouse model of AGA, and MMP9 inhibitor would provide an additional option for male AGA treatment.