On the other hand, mast cell decreases dramatically during anagen, while γδT cell numbers remain unchanged during the hair cycle.[16,17] Mast cell play an important role in fibrotic,[18] and research have proved fibrosis occurs in the bulge region of AGA-affected HFs and correlates with their miniaturization stage.[19] In our study, γδ T cell, central memory CD8+ cell and mast cell were significantly more infiltrated in the bald group than in the haired group. The gene discussed is CD8A; the disease is Hand-foot syndrome.