RUNX1 and leukemia: Consistent, with this finding, TAF1 upregulates cyclin D and cyclin A expression through TAF1 histone acetyltransferase activity (Jacobson et al., 2000) and TAF1 has been shown to associate with the leukemia-promoting oncogene AML1-ETO, which promotes proliferation of AML1-ETO-expressing myeloid leukemia cells.