Treatment options for pediatric patients with HAE include on‐demand therapy with plasma‐derived C1‐INH, recombinant C1‐INH, and icatibant, as well as pre‐procedural (e.g., before dental extractions) and long‐term prophylaxis with plasma‐derived C1‐INH (Table 3). The gene discussed is SERPING1; the disease is hereditary angioedema.