Compared with T2D controls, patients with AS showed no significant differences in BMI, but had lower HbA1c levels (Table 3), higher NT-proBNP levels (T2D controls, 89 ng/L [33–142] versus AS, 381 ng/L [185–1404]; P<0.0001), and reduced 6-minute walk distance (T2D controls, mean, 455 meters [95% CI, 412, 499] versus AS, mean, 386 meters [95% CI, 360, 412]; P=0.01). The gene discussed is NPPB; the disease is aortic stenosis.