Moreover, Rcn1 knockdown did not decrease the viability of Raw264.7, another mouse AML cell line, which lacks the apoptosis‐associated speck‐like protein that contains a carboxyl‐terminal CARD (ASC) and, therefore, cannot activate caspase‐1 (Fig. 6E) [54]. This evidence concerns the gene RCN1 and acute myeloid leukemia.