After stringent quality control and filtering using multiple criteria, the transcriptomes of 1321 and 804 single cells (AML/M5‐sh‐ctrl and AML/M5‐sh‐RCN1) were acquired, and a mean of 2865 and 2782 genes were detected per cell, respectively (Fig. 2B and Fig. S1A–C). This evidence concerns the gene RCN1 and acute myeloid leukemia.