Impaired Nrf2 signaling reduces iron storage into ferritin in the streptozotocin-induced type 1 diabetes mellitus (T1DM) heart, while it downregulates ferroportin-1 compromising iron export in the high-fat diet and streptozotocin-induced T2DM heart (9, 45). The gene discussed is SLC40A1; the disease is type 1 diabetes mellitus.