PC: pancreatic cancer; AUC: area under the curve; PDAC: pancreatic ductal adenocarcinoma; CP: chronic pancreatitis; AP: acute pancreatitis; EV: extracellular vesicles; EV: extracellular vesicles; AIP: auto-immune pancreatitis; MAPK: mitogen-activated protein kinase; HC: healthy control; CA 19-9: carbohydrate antigen 19.9; TP: true positive; FP: false positive; TN: true negative; FN: false negative; OS: overall survival. The gene discussed is WNK2; the disease is autoimmune pancreatitis.