AT2 increases oxidative stress, causes neuro-inflammation, and exhibits anticholinergic properties, all of which, as mentioned above, leads to decreased clearance of Aß plaques [10].AT2, after its production, can take part in 4 different pathways [11]: a) ACE1/AT2/AT1 receptor (AT1R): This pathway is responsible for the role that AT2 plays in AD. The gene discussed is ACE; the disease is Alzheimer disease.