In patients, DRB1*04 and *10 were strongly associated with RA susceptibility (9.6% vs. 5.1%, P = 0.04, OR (95% CI) = 0.47 (0.32-0.54) and 14.2% vs. 8.2%, P = 0.04, OR (95% CI) = 1.86 (0.99-3.48)), with ACPA seropositivity patients (22.2% vs. 8.8%, P = 0.04, OR (95% CI) = 2.97 (1.00-8.87) and 23.8% vs. 8.8%, P = 0.03, OR (95% CI) =3.25 (1.10-9.62), respectively), and were high in frequency between the RA ethnic groups compared with the healthy controls. Here, PRTN3 is linked to rheumatoid arthritis.