Case Report: <i>ASXL1</i>, <i>RUNX1</i>, and <i>IDH1</i> mutation in tyrosine kinase-independent resistant chronic myeloid leukemia progressing to chronic myelomonocytic leukemia-like accelerated phase. The gene discussed is RUNX1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.