Inducible ablation of LOXL2 expression using lentiviral delivered shRNA reduced incidence of primary tumor growth in the mouse model (LOXL2 ablation with doxycycline addition - 40% (6/15 mice) versus vehicle only - 66% (10/15 mice) (Figures 6B, C). This evidence concerns the gene LOXL2 and neoplasm.