Multivariate analysis indicated that histology (signet-ring cell carcinoma vs. adenocarcinoma, HR: 2.93, 95% CI: 1.50-5.74, p=0.002) and SII (≥448.1 vs. <448.1, HR: 2.06, 95% CI: 1.03-4.12, p=0.040) were independent prognostic factors for OS in patients with HER2-negative AGC (Table S4; Figure 7A). Here, ERBB2 is linked to signet ring cell carcinoma.