<h4>Background</h4>Previous genetic-epidemiological studies considered <i>TERT</i> (rs2736100), <i>CCDC26</i> (rs4295627), <i>CDKN2A/B</i> (rs4977756) and <i>RTEL1</i> (rs6010620) gene polymorphisms as the risk factors specific to glioma. The gene discussed is TERT; the disease is central nervous system cancer.