According to data analysis results, in four genetic models (AM, RM, DM and C-DM) <i>TERT</i> gene rs2736100 polymorphism, <i>CCDC26</i> gene rs4295627 polymorphism, <i>CDKN2A/B</i> gene rs4977756 polymorphism and <i>RTEL1</i> gene rs6010620 polymorphisms increased the risk of glioma in Caucasians to different degrees. Here, CDKN2A is linked to central nervous system cancer.