LGR5 and intestinal neoplasm: Interestingly, mice with one allele of Msh2 deleted throughout the body and another allele specifically deleted in Lgr5+ cells (Lgr5-CreERT2;Msh2flox/-) survived longer (average 19 months) and had low penetrance of intestinal tumors (40%) (85) compared to VCMsh2 mice with both alleles of Msh2 deleted in Lgr5+ and TA cells (19) (median survival of 11.6 months, with 100% penetrance; data not shown).