MRC1 and cancer: Thus, carriers with pathogenic MMR variants usually have an increased lifetime risk for developing various cancers with early cancer onset (e.g., colorectal cancer [CRC] or hereditary non-polyposis colorectal cancer [HNPCC], endometrial cancer, gastric cancer, and ovarian cancer mainly for LS, and brain cancer, gastrointestinal cancer, and lymphomas for CMMRD) (1, 2).