The upregulated and downregulated lncRNAs in HCC have been summarized in a previous review; most lncRNAs were significantly associated with clinicopathologic features, including the tumor size, focality, differentiation, invasion, tumor stage, metastasis, presence of cirrhosis, alpha fetoprotein levels, and hepatitis B virus infection status (19). This evidence concerns the gene AFP and hepatocellular carcinoma.