GADD45B and pachyonychia congenita: The only known PC aggressiveness gene that remained significant after adjusted analysis was FOXM1 (adjusted Cox proportional hazards model p-value = 0.048), which was less significant compared to the identified four biological aging genes (Figure 5B, right-most genes: CD44 adjusted p-value = 0.00054, GADD45B adjusted p-value = 0.0084, STAT3 adjusted p-value = 0.0167, GFAP adjusted p-value = 0.036).