Interestingly, the secretion of bFGF depends on Axl expression (Figures 6A, B) rather than on the synergism of Axl and ErbBs as treatment of Rego-resistant HCC cells with Afatinib did not affect the release of bFGF into supernatants (data not shown). The gene discussed is FGF2; the disease is hepatocellular carcinoma.