Considering that in WNT-activated medulloblastomas, CTNNB1 wild-type cases can harbor APC germline mutations, our study suggests that up to 27% of Latin-Iberian WNT-activated medulloblastomas can occur in the context of FAP, contrasting with the reported approximately 10% in North American and European populations. The gene discussed is APC; the disease is medulloblastoma.