showed that miRNA let-7a overexpression significantly suppressed the activity of the MAPK signaling pathway by downregulating Ras, p-Raf1/Raf1, and p-MEK1/MEK1 via targeting Rsf-1 in LC cells, resulting in the repression of cell proliferation after radiotherapy (85). This evidence concerns the gene RAF1 and laryngotracheoesophageal cleft.