Recently, it has been found that in non-Tfh-derived T-cell lymphomas like PTCL-NOS, gene regulators like t-bet, GATA-3, and FoxP3 regulate the differential expression of their target genes including those cytokines that regulate the constituents of the TME (64–66). This evidence concerns the gene GATA3 and T-cell non-Hodgkin lymphoma.