The case of systemic anaplastic large cell lymphomas (ALCL), in which NPM-ALK (nucleophosmin-anaplastic lymphoma kinase) translocation fuses the catalytic domain of ALK with the dimerization domain of NPM, results in autophosphorylation of ALK resulting in activation of the pathways which are either redundant with RAS/RAF/ERK and P13K/STAT-3 pathway or complimentary to the JAK3/STAT3 pathway (38, 216, 222, 223). This evidence concerns the gene STAT3 and anaplastic large cell lymphoma.