Phosphorylation of Akt, an important component associated with cytokine downstream signaling, is a clear indicator of poor patient survival, and the level of phosphorylated PTEN (Phosphate and TENsin homolog) (inhibitor of PI3K-downstream signaling) is inversely associated with the later clinical phase of MF (69, 78–80). This evidence concerns the gene PTEN and mycosis fungoides.