This lymphotoxin β  is suspected to be involved in the induction of FDC proliferation, and these FDC of the TME may show an abnormal expression of FDC-specific markers such as CD23 and CD21, but a direct link between abnormal expression of CD21 along with CD-23 with development of FDC neoplasm has not been reported (58, 151, 153, 168). This evidence concerns the gene CR2 and neoplasm.