NFKB1 and primary cutaneous T-cell non-Hodgkin lymphoma: Kinases like TAK1 are the main regulator of NF-κβ, and the level of TAK1 has been reported to be upregulated in CTCL, but inhibition of TAK1 hampers the NF-κβ pathway, resulting in the induction of apoptosis in the CTCL cell line in both in vitro and in vivo conditions (69, 113, 114).