CD8A and angioimmunoblastic T-cell lymphoma: The role of T-cell mediated response is not clear, but CD8+ T cells are suspected to play an immunosuppressive role; usually, the TME of AITL is immunosuppressive which is evident by the low number of Treg cells together with M2 macrophage expansion and Th17 cell accumulation (142, 148, 152, 175, 176).