POU5F1 and neoplasm: Similarly, having an elevated ΔCEA and negative ΔOCT4/GUSB were significantly associated with undifferentiated tumor phenotype (PR 1.82; 95% CI: 1.12 - 2.97, p=0.006), advanced tumor progression stage (PR 2.36; 95% CI: 1.30 - 4.27, p <0.001), and initial positive expression of OCT4 (PR 7.73; 95% CI: 2.02 - 29.54, p <0.001) compared to not having this status (Table 7).