Being OCT4 positive and having an elevated ΔCEA value were significantly associated with undifferentiated tumor phenotype (PR 2.02; 95% CI: 1.21 - 3.37, p=0.002), advanced tumor progression stage (PR 2.36; 95% CI: 1.30 - 4.27, p <0.001), and negative values of ΔOCT4 (PR 21.06; 95% CI: 3.04 - 145.7, p <0.001) and ΔOCT4/GUSB (PR 12.29; 95% CI: 3.17 - 47.61, p <0.001) (suggestive of poor therapeutic response) compared to those without this status. Here, GUSB is linked to neoplasm.