P2RY13 and acute myeloid leukemia: The intrinsic chemoresistance of AML blasts is at least partly contributed by CD39-mediated activation of the P2RY13-cAMP-PKA pathway and the ATF4 axis, triggering mitochondrial ROS production and OXPHOS activity that leads to chemoresistance with heightened antioxidant defenses by AML cells (74).