Several proteins involved in mitochondrial calcium signaling are aberrantly expressed and located on the surface of AML cells and LSCs; these include oxysterol-binding protein (OSBP)-related proteins (ORPs), transient receptor potential melastatin 2 (TRPM2), and neurokinin-1 receptor (NK-1R). This evidence concerns the gene TRPM2 and acute myeloid leukemia.