The all-CLL panel was customized from a predesigned SOPHiA GENETICS capture-based NGS panel to cover 16 CLL driver genes [TP53, NOTCH1, SF3B1, ATM, BIRC3, EGR2, FBXW7, NFKBIE, POT1, XPO1, KRAS, MYD88, CXCR4, BTK, PLCG2, and BCL2], 4 CNAs [del(17p), del(11q), del(13q), and trisomy 12], full-length IGH V(D)J gene rearrangements (from FR1 to FR4) and IGHV gene SHM, and full-length IGLV3-21 gene rearrangements allowing the determination of the R110 mutation (region of interest: 74 Kb; Figure 1A; Supplemental Digital Content; Suppl. The gene discussed is BTK; the disease is B-cell chronic lymphocytic leukemia.