In a clinical trial, it was found that the plasma concentrations of syndecan-1 (SYN-1) and VE-cadherin (endothelial cell junctions) in septic shock patients significantly increased within 7 days, patients with more severe diseases have higher concentrations of SYN-1 and VE-cadherin in their plasma, while lower levels of S1P, demonstrate a close correlation between S1P and endothelial damage in patients with septic shock (118). Here, CDH5 is linked to septic shock.