We reported here no major role for Lcn2 in LPS-induced ALI, while it was recently reported that Lcn2−/− mice had relatively increased survival than control mice following intratracheal administration of LPS (43); the contradiction could be due to experimental design, dose, and species of administered LPS, as well as the local microbiome of the animal houses. The gene discussed is LCN2; the disease is acute respiratory distress syndrome.