In addition to vitamin A derivative, retinal acid, a cocktail of ATRA, TGFβ inhibitors, GSK3β inhibitors, and H3K9 methyltransferase/G9a inhibitors have been successfully used to induce differentiation, including hepatoma cell lines, primary hepatoma cells, liver cancer stem cells, and drug resistant hepatoma cells (Zhang et al., 2022a). The gene discussed is GSK3B; the disease is hepatocellular carcinoma.