EHMT2 and hepatocellular carcinoma: In addition to vitamin A derivative, retinal acid, a cocktail of ATRA, TGFβ inhibitors, GSK3β inhibitors, and H3K9 methyltransferase/G9a inhibitors have been successfully used to induce differentiation, including hepatoma cell lines, primary hepatoma cells, liver cancer stem cells, and drug resistant hepatoma cells (Zhang et al., 2022a).