GLI2 and postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome: The GLI2 gene has been linked to Culler-Jones syndrome and Holoprosencephaly 9 (HPE9), and studies have reported that patients with pathogenic variants of the GLI2 gene demonstrate an autosomal dominant inheritance pattern, variable expressivity and incomplete penetrance (Elward et al., 2020).