Case 8, with prenatal ultrasound detecting cleft palate, micrognathia, polyhydramnios, and bilateral subependymal cysts, was found to harbor a missense variant (c.3449G>T; p.(Gly1150Val)) in COL11A1, further highlighting the phenotypic overlap and extensive phenotypic variation occurring in collagenopathies caused by COL2A1 and COL11A1. Additionally, these two novel described variations were the first reported, and served to expand the variation spectrum associated with the COL2A1 and COL11A1 genes. Here, COL2A1 is linked to cleft palate.