The most common mutations occurred in the following genes: TET2, DNMT3A, TP53, and ASXL1. Shorter survival was associated with mutations in DNMT3A, SRSF2, SF3B1, IDH1/2, and RUNX1. The presence of additional mutations was associated with patients who transformed into AML or MF. This evidence concerns the gene RUNX1 and acute myeloid leukemia.