Amplifications of CCDN1, FGF19, FGF3, FGF4, SOX2, PI3KA, and MAP3K13 were observed more frequently in ESCC, whereas amplifications of ERBB2, KRAS, CCNE1, RARA, GATA4, and VEGFA were more common in EAC. The gene discussed is FGF3; the disease is esophageal squamous cell carcinoma.