Regarding genomic amplification, it was noted that CCDN1, FGF19, FGF3, FGF4, SOX2, PI3KA, and MAP3K13 were frequently amplified in ESCC, whereas ERBB2, KRAS, CCNE1, RARA, GATA4, and VEGFA amplifications were more common in EAC in this study, as similar to the literature. The gene discussed is GATA4; the disease is esophageal squamous cell carcinoma.