ERBB2, KRAS, SMAD4, and TACC3 gene alterations were predominantly observed in EAC, whereas CCDN1, NFE2L2, FGF19, FGF3, FGF4, NOTCH1, and CDKN2B gene alterations were mostly observed in ESCC. The gene discussed is SMAD4; the disease is esophageal squamous cell carcinoma.