Amplifications of CCDN1, FGF19, FGF3, FGF4, SOX2, PI3KA, and MAP3K13 were observed more frequently in ESCC, whereas amplifications of ERBB2, KRAS, CCNE1, RARA, GATA4, and VEGFA were more common in EAC. This evidence concerns the gene SOX2 and esophageal squamous cell carcinoma.