Furthermore, mediator MR analysis reveals that retinoic acid receptor responder protein 1 and C-type lectin domain family 4 member D play a critical mediating role in the causal pathway from HannumAge to cancer, which suggesting that retinoic acid receptor response protein 1 and C-type lectin domain family 4 member D may serve as a potential drug target for the treatment of lung cancer. The gene discussed is RARRES1; the disease is cancer.