Loss of heterozygosity (LOH) for material at 11q13 including the MEN1 locus was a distinctive genetic change in this tumor (19–21); Heterozygous deletion (LOH) on chromosome 10p14-p15 associated with lung carcinoid tumor (40); High expression of Sox2 and p63 may affect tumor differentiation in pulmonary neuroendocrine tumors (41); Loss of expression of the OTP gene and the stem cell marker CD44 was associated with poor prognosis (42); fascin immunoreactivity may identify subgroups of lung carcinoid patients with different potential for regional lymph node metastasis (43). This evidence concerns the gene SOX2 and lung neuroendocrine neoplasm.