This study found that the detection rates of clinical hyperthyroidism, subclinical hyperthyroidism, clinical hypothyroidism, and goiter in Qinghai Province (1.20%, 0.20%, 1.00%, 2.10%) were similar to the overall national level (0.78%, 0.44%, 1.02%, 1.17%) during the same period of the TIDE study, and the positive rates of TPO Ab and TG Ab antibodies (9.80%, 9.20%) were also relatively stable compared to the TIDE study (10.19%, 9.70%). The gene discussed is TPO; the disease is hyperthyroidism.