Their examples in the uterus are p53-mutant endometrial cancers (such Ishikawa cells) which are characterized by poor outcomes and cervical cancers associated with HPV infection which frequently have downregulated p53 level and transcriptional activity (such HeLa cells) (St John et al., 2000; Bouaoun et al., 2016). The gene discussed is TP53; the disease is endometrial cancer.