We employed dox-inducible HIF-2α with or without intact STMs (HIF-2α ref-seq NP_001421.2 Δ455-470; Δ776-791, called ΔSTMs) in MCF7 cells, a breast cancer cell line with low endogenous HIF-2α protein levels (Fig 3A; Fig S3A, left). Here, EPAS1 is linked to breast cancer.