We used these rules to simulate 5 days of growth of a 2-D tumor in a virtual environment of 38 mmHg oxygenation (physioxic conditions65), starting with 1000 viable tumor cells, surrounded by a ring comprised of 200 Naive CD8+ T cells and 200 M0 Macrophages (Fig. 5). The gene discussed is CD8A; the disease is neoplasm.