In this study, we analyzed the TCGA database of melanoma versus normal tissue, BRAF mutated melanoma versus BRAF wild-type melanoma and obtained a total of 24 differential genes, i.e., 22 up-regulated differential genes and two down-regulated differential genes, including TP53, MMPs, and other recognised melanoma oncogenes (Weiss et al., 2022). The gene discussed is TP53; the disease is melanoma.