SNX10, S100B, CSPG4, AIM2, FDCSP, KCNJ10, COL22A1, ITIH6, IL27RA, SERPINE2, OLIG1, CD200, METTL7B, and TIMP1 were found to be highly expressed in melanoma, yet negatively correlated with prognosis, i.e., the prognosis is better when the expression is higher. The gene discussed is SERPINE2; the disease is melanoma.